骨形成蛋白-2对大鼠正畸牙移动后根吸收早期修复的影响

Effect of Bone Morphogenetic Protein-2 in Early Orthodontically Induced Root Resorption Repair in Rats

目的:观察正畸诱导牙根吸收后骨形成蛋白-2对牙根早期修复的影响。方法:60只SD大鼠,在建立正畸牙根吸收模型后随机分为:Force组(继续加力)、Control组(停止加力)和BMP-2组(停止加力并牙周膜内注射BMP-2),在分组后第0、5、10和15天分别处死并行组织形态学分析。结果:BMP-2组修复性牙骨质生成明显较Force、Control组早,且量大(P<0.01);BMP-2、Control组牙根吸收和破牙细胞数明显较Force组少(P<0.01)。结论:停止加力并局部使用BMP-2能有效促进因正畸吸收后牙根的早期修复。

Objective：To investigate the role of BMP-2during early cementum repair following orthodontically induced root resorption.Methods：Sixty SD rats were randomly divided into force group（continuous force）,control group（withdrawal force）and BMP-2group（withdrawal force and BMP-2periodontal ligament injection）after orthodontically induced root resorption occurred.After 0,5,10and 15days,the animals were sacrificed and maxillae were prepared for histological and histomorphometric analysis.Results：The formation of reparative cementum was earlier and more significant in BMP-2group than the force and control group（P0.01）.Root resorption and the number of odontoclasts in BMP-2and control group were significantly less than those of force group（P0.01）.Conclusion：These results indicate that the intraperitoneal application of BMP-2and release of the orthodontic force enhance the early orthodontically induced root resorption repair.