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MicroRNAs的分子进化与调控机制 被引量：9

Molecular evolution and regulatory mechanism of microRNAs
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摘要 MicroRNAs(miRNAs)是一类专门调控基因表达的非编码小分子RNA,广泛参与生物发育、细胞分化、细胞凋亡等多种生命进程。miRNAs在不同种系间独立进化且在进化演变中普遍保守。文章综述了miRNAs起源、进化上的保守性及甲基化调控方面研究进展,另外在疾病和动植物应用方面的研究也作了较为详细的阐述。 MicroRNAs, a type of small non-coding RNA specialized in regulation of gene expression, extensively participate in biological development, cell differentiation, apoptosis, and other cellular processes. MiRNAs evolved independently in different strains and generally conserved in the process of evolution. This review summarized the origin, regulation of methylation, and evolutionary conservation of miRNAs. In addition, application of miRNAs in diseases, animals and plants was discussed.
作者 王天宇 董园园 李海燕 李校堃
机构地区 吉林农业大学生物反应器与药物开发教育部工程研究中心 吉林农业大学生命科学学院
出处 《遗传》 CAS CSCD 北大核心 2010年第9期874-880,共7页 Hereditas（Beijing)
基金 国家高技术研究发展计划项目(863计划)(编号:2007AA100503)资助
关键词 小分子RNA 微小RNA进化 甲基化 miRNA microRNA evolution DNA methylation
分类号 Q522 [生物学—生物化学]
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2010年 第9期

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