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AG1478对大鼠脊髓损伤后反应性星形胶质细胞增生的影响 被引量：1

Effects of AG1478 on Reactive Astrogliosis of Rats with Spinal Cord Injury
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摘要 目的:研究表皮生长因子受体(EGFR)抑制剂AG1478对大鼠脊髓损伤后反应性星形胶质细胞增生的影响。方法:SD大鼠60只,随机分为对照组,AG1478组和假手术组,各组20只。观察AG1478对大鼠脊髓损伤后磷酸化表皮生长因子受体(pEGFR)和胶质纤维酸性蛋白(GFAP)的表达、髓鞘脱失、神经功能恢复及体重的影响。结果:AG1478组大鼠pEGFR和GFAP的表达较对照组明显减弱(P<0.01),损伤区脱髓鞘范围明显较对照组减小(P<0.01),BBB评分明显高于对照组(P<0.01),体重较对照组增加更明显(P<0.05)。结论:AG1478可能通过阻断星形胶质细胞上的EGFR通路抑制胶质增生,促进脊髓损伤大鼠神经功能的恢复。 Objective： To investigate the effects of EGFR inhibitor AG1478 on reactive astrogliosis of rats with spinal cord injury（SCI）.Methods： Sixty SD rats were randomly divided into control group（n=20）,AG1478 treatment group（n=20） and sham operation group（n=20）.The expression of phosphorylated epidermal growth factor receptor（pEGFR） and glial fibriliary acidic protein（GFAP）,demyelination,neuronal function recovery and body weight of rats after SCI were observed.Results： Compared with the control group,the expression of pEGFR and GFAP was significantly lower（P0.01）,the area of the demyelination region smaller（P0.01）,the BBB scores higher（P0.01） and the body weight of rats heavier（P0.05） in AG1478 treatment group.Conclusion： Administration of AG1478 could suppress the reactive astrogliosis of rats with SCI by blocking the EGFR pathway in astrocytes.
作者 李在望 唐荣华 张剑平 詹艳 田代实 王伟
机构地区 华中科技大学同济医学院附属同济医院神经科 南京医科大学附属无锡市人民医院神经内科
出处 《神经损伤与功能重建》 2010年第5期338-342,共5页 Neural Injury and Functional Reconstruction
基金 国家自然科学青年基金项目(No.30800340) 教育部博士点新教师基金(No.200804871060)
关键词 AG1478 表皮生长因子 脊髓损伤 反应性胶质增生 AG1478 EGFR spinal cord injury reactive astrogliosis
分类号 R741 [医药卫生—神经病学与精神病学] R744 [医药卫生—神经病学与精神病学]
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参考文献16

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二级参考文献7

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同被引文献19

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神经损伤与功能重建
2010年 第5期

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