骨髓活检病理学检测在血液病诊断和鉴别诊断的价值

Clinic value of bone marrow histopathology in diagnosis and differential diagnosis of hematonosis

目的探讨骨髓活检和骨髓涂片在血液病诊断中的意义。方法对650例血液病患者,分别进行外周血采集,骨髓活检和骨髓穿刺,分别观察骨髓涂片和骨髓活检切片。结果骨髓活检切片能准确地反映骨髓细胞增生程度,对恶性细胞的检出率更高。在淋巴瘤、骨髓纤维化、骨髓增生异常综合征、骨髓转移癌、多发性骨髓瘤诊断方面,骨髓活检优于涂片。结论骨髓活检和涂片同步观察能有效提高血液病的诊断率,减少误诊率,并正确判断疾病的分期。

Objective To study the diagnostic significance of synchronism observation on both marrow biopsy and marrow smear in hematological diseases. Methods The marrow samples of 650 patients with hematological diseases were detected by peripheral blood smear, bone marrow biopsy and bone marrow smear. Those sections and smears were observed. Results Bone marrow biopsy showed the hyperplasia of bone cells more accurately and had a higher checkout rate of the malignant cells. Biopsy prefered to smear in the diagnosis of diseases such as lymphoma, myelofibrosis, myelodysplastic syndrome, metastatic carcinoma of bone marrow and multiple myeloma. Conclusion Bone marrow biopsy and bone marrow smear synchronous observation can effectively increase the diagnosis rate, decrease misdiagnosis rate, and judge correctly the stage of the disease.