同型半胱氨酸和尿酸水平与急性冠脉综合征病情进展的相关性

Relationship between levels of plasma homocysteine and serum uric acid and progression of acute coronary syndrome

目的探讨急性冠状动脉综合征(acute coronary syndrome,ACS)病情进展与血浆同型半胱氨酸(homocysteine,Hcy)和血清尿酸(uric acid,UA)水平的相关性。方法选择58例ACS患者(ACS组,AMI 30例,UAP 28例),30例稳定型心绞痛(SAP组),30例同期健康成人(对照组),分别检测血浆Hcy和血清UA。结果 ACS患者血浆Hcy与血清UA显著高于SAP组(P<0.05)和对照组(P<0.05),ACS组内AMI亚组高于UAP亚组(P<0.05)。结论血浆Hcy和血清UA含量与ACS患者病情进展呈正相关,二者是冠心病危险性的预测因子。

Objective To investigate the relationship between the levels of plasma homocysteine （Hcy） and serum uric acid （UA） and acute coronary syndrome（ACS）. Methods From 88 subjects and 30 healthy controls, plasma Hey and serum UA were assayed. The subjects were divided into two groups, ACS group （58 cases including, AMI 30 cases and UAP 28 cases） and SAP group （30 cases） , and 30 healthy persons as controls. Results The levels of Hcy and UA in ACS group were significantly higher than those in SAP group（P 〈 0.05） and control group （ P 〈 0.05 ） , and within ACS group both levels of AMI subgroup were higher than those of SAP subgroup（P 〈 0.05）. Conclusion The levels of plasma Hcy and serum UA are closely associated with ACS progression, and the increased Hey and UA may be important risk factors ror ACS.