氧化苦参碱降低盆腔放疗患者血清TGF-β1、FN的含量及其意义

Effect and significance of Oxymatrine on serum TGF-β_1,FN in Pelvic Irradiation Patients

目的:对放疗患者应用氧化苦参碱观察其是否具有阻断正常组织放射性损伤的生物活性。方法:78例确诊的妇科肿瘤患者随机分为治疗组和对照组,两组均进行单纯盆腔野根治性放疗,治疗组用岩舒注射液静滴。采用酶联免疫吸附法(ELISA)动态检测所有患者放疗过程中及放疗后血清转化生长因子-β1(TGF-β1)、纤维连接蛋白(FN)的含量。结果:氧化苦参碱能降低血清TGF-β1的含量,但反应较迟缓,对于晚期的放射性损伤可能更具有临床意义。放疗过程中氧化苦参碱能明显降低血清FN含量,预防急性放射性损伤的发生。结论:氧化苦参碱可以干预盆腔组织放射性损伤的发生。

Objective：To observe the effect of blocking normal tissue radiation injury by Oxymatrine for patients treated by radiation therapy. Methods： Seventy eight cases of gynecologic cancer patients were randomly divided into treatment group and control group, two groups were treated by pelvic radiotherapy, the treatment group with intravenous infusion of Oxymatrine. During and after radiotherapy, Enzyme-linked immunosorbent assay （ELISA） was used for all patients to test the serum transforming growth factor-β1 （TGF-β1）, fibronectin （FN）. Results： Oxymatrine could reduce the level of serum TGF-β1, slowly, for the late radiation injury may have more clinical significance. In the course of radiotherapy, Oxymatrine could significantly reduce serum FN level, and preven acute radiation injury. Conclusion： Oxymatrine can interfere the occurrence of pelvic radiation damage.