卵巢透明细胞癌18例临床分析

Clinical analysis of 18 cases of ovarian clear cell carcinoma

目的:分析18例卵巢透明细胞癌的临床特点、预后及与子宫内膜异位症的关系。方法:对18例原发性卵巢透明细胞癌患者回顾性分析其治疗方法、对化疗的敏感性和生存率,以及合并子宫内膜异位症患者对化疗的敏感性和生存率。结果:卵巢透明细胞癌患者常发生月经紊乱或绝经后出血,I期患者比例较高,多发生于单侧卵巢,常伴发卵巢子宫内膜异位症,是否合并子宫内膜异位症对化疗的敏感性和生存率无统计学差异。结论:卵巢透明细胞癌临床特点不同于其他的卵巢上皮性恶性肿瘤,其临床分期早,对化疗不敏感,易复发,预后差。伴有子宫内膜异位症与否与预后无相关性。本病预后与临床分期直接相关,与肿瘤体积、有/无腹水、肿瘤扩散程度、肿瘤侵犯单侧或双侧卵巢等因素密切相关。

Objective：To analyse the clinical and pathological characteristics and prognosis of ovarian clear-cell carcinoma, and its relation with endometriosis. Methods： Eighteen cases with primary ovarian clear-cell carcinoma patients were analyzed retrospectively. Results： As compared with the ovarian serous cystadenocarcinoma, the patients with ovarian clear cell carcinoma more often had unusual menstrual cycle or postmenopause bleeding, took place in unilateral ovary, accompanied with endometriosis and the proportion of FIGO stage I was higher. The incidence of endometriosis showed no significant difference between the groups. Conclusion： Unlike other ovarian epithelial carcinoma, clear cell carcinoma＇s clinical stage is early but isn＇t sensitive to chemotherapy. It easily recurs at early time with poor prognosis. Pathological results don＇t show any correlation between endometriosis and the prognosis of ovarian clear-cell carcinoma.The prognosis of ovarian clear cell carcinoma is correlated with clinical staging, size of tumours, presence of ascites, the degree of dissemination, invasion of one or both sides of the ovary and differentiation of the tumour cells.