硅胶柱层析法分离提纯双基药中的硝化甘油

Separation and Purification of Nitroglycerine from Doublebase Propellant by Silica Gel Column Chromatography

探讨了以双基药为原料,采用柱层析法分离提纯来获取少量硝化甘油的工艺方法。结果表明,以乙醚为提取溶剂、二氯甲烷为流动相,45-75μm的层析用粗孔硅胶为固定相,空塔流速约为0.764 cm/min的条件下进行层析柱分离提纯,可获取克量级的硝化甘油。经高效液相色谱法分析,所得硝化甘油纯度高,未见杂峰。

In order to obtain a certain amount of pure nitroglycerine from double-base propellant simply in the laboratory, the process about the separation and purification of nitroglycerine by silica gel column chromatography was studied. The results showed that suitable operation conditions were diethyl ether as extraction solvent, dichloromethane as mobile phase, silica gel with diameter of 45-75μm as stationary phase and the flow rate of 0. 764cm·min^-1. Under the above mentioned operation conditions, gram magnitude of nitroglycerine could be obtained. The product was analyzed by high performance liquid chromatography, indicating that the purity of the obtained nitroglycerine was high, and there were no other impure peaks.