摘要
目的检测Twist蛋白在非小细胞肺癌（NSCLC）的表达及与临床病理学指标的关系，探讨Twist蛋白在肺癌中的应用价值。方法应用免疫组织化学方法检测54例NSCLC肺癌标本组织、10例正常肺组织和10例肺良性病变中Twist的表达。结果Twist在NSCLC癌组织、正常肺组织和肺良性病变组织中的表达率分别为68．52％、10％和20％，T、visc在NSCLC癌组织中的表达明显高于正常肺组织和肺良性病变组织（P〈0．05）；Twist在NSCLC癌组织中表达与肿瘤的分化程度、临床分期及淋巴结转移有关；而其表达与病人年龄、性别及肿瘤的病理类型无关。结论Twist蛋白的表达与肺癌的发生发展及浸润转移有关，在判断肿瘤分化程度、分期、淋巴结转移及预后等方面均具有较好的辅助诊断价值。
Qbjective To investigate the expression and its clinicopathological significance of Twist innon-small-cell lung cancer （NSCLC） tissues. Methods The expression of Twist in 54 cases of NSCLC tissues, 10 cases of normal lung tissues andl0 cases of benign lesion of lung was detected by using immunohistochemistry.Result The positive rates of Twist in NSCLC , normal lung tissues and benign lesion of lung were 68.52%, 10% and 20%, respectively. The positive rates of Twist in NSCLC was higher than that in normal lung tissues and benign lesion of lung .The difference of Twist expression was not significant in different groups of the age, gender of patients and pathologic type, while it was significant in group of tumor differentiation, clinical stage and lymphatic metastasis. Conclusion Twist may be play an important role in the tumorigenesis and metastasis of lung cancer. The expression of Twist may be a useful marker in clinicopathological diagnosis and prognosis of lung cancer.
