基质碱金属蛋白酶与早产
摘要
早产是指妊娠满28周至不足37周之间终止者,目前,全球发病率保持在10%左右。早产儿由于器官功能不成熟和免疫功能不完善,产生许多并发症而生存率低下,75%~80%的围生儿死亡和早产有关。近年来,对早产的研究颇多,但早产发生的原因和发病机制尚未完全明了。基质碱金属蛋白酶(LOMTs)是一族能降解细胞外基质(ECM)中所有蛋白成分的内源性酶,可调控ECM的含量,与早产密切相关。
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