摘要
目的探讨依托泊苷亚微乳注射液处方成分配比及制备工艺。方法以依托泊苷亚微乳注射液的粒径与分布、包封率及外观稳定性为评价指标,对其制备过程中的影响因素及处方成分配比等进行考察。结果依托泊苷亚微乳注射液pH在4.0～6.5之间,高压均质操作在25℃下进行,均质压力为800bar,均质6～10次可以得到粒径200nm以下且分布较均匀的亚微乳注射液。结论该法制备的依托泊苷亚微乳注射液性质稳定,方法可行。
Objective To determine the etoposide-loaded submicro-emulsion formulation and preparation process.Methods The stability of etoposide-loaded submicro-emulsion was used as the main evaluation index,and the main technological factors and formulation factors during the preparation of etoposide-loaded submicro-emulsion were studied.Results A diameter of about 200 nm and more even distribution of etoposide-loaded submicro-emulsion were obtained under the following condition：the pH value was 4.0-6.5;homogenization cycle was 6-10 times at a homogenization pressure of 800 bar at temperature of 25℃.Conclusion This method is feasible.
出处
《解放军药学学报》
CAS
2010年第4期297-300,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
依托泊苷
亚微乳注射液
工艺
处方
etoposide
submicro-emulsion
preparation
formulation
