吡格列酮联合穴位注射治疗阿尔茨海默病临床观察

Clinical Observation of Therapeutic Effects of Pioglitazone Combining Acupuncture Point Injection on Alzheimer's Disease

目的:探讨吡格列酮联合穴位注射治疗阿尔茨海默病的疗效观察。方法:治疗组30例用吡格列酮、穴位注射脑活素治疗持续24周,对照组30例用双氢麦角碱、吡拉西坦治疗持续治疗24周,分别于治疗后6周、12周、24周进行疗效评估。结果:吡格列酮、穴位注射脑活素治疗24周后,用ADAS-cog评分比治疗前有显著意义的提高,且远期评分更有意义。结论:吡格列酮联合穴位注射脑活素治疗可改善阿尔茨海默病的ADAS-cog评分和临床症状,且远期疗效优于对照组。

Objective：To probe the therapeutic effects of pioglitazone combining acupuncture point injection on Alzheimer＇s disease. Methods：The 30 patients of treated group were continuously treated with pioglitazone combining acupuncture point injection for 24 weeks. The 30 patients of control group were continuously treated with topiramate alkaline combining plracetam for 24weeks.The therapeutic effects were respectively assessed in 6th week,12th week,24th week after treatment by the ADA-cog score and long-term score.Results：After treatment,the ADA-cog score was significantly improved in the group treated with pioglitazone combining topiramate alkaline compared with prior treatment .In addition, the long-term score was more meaningful.The therapeutic effects were statistically significant in treated group compared with control group.Conelusion：Pioglitazone may improve the symptoms of Alzheimer＇s disease.The long-term therapeutic effects in treated group were more than contol goup.