摘要
目的:评价奥拉西坦对脑梗死急性期认知功能障碍的改善作用,评估其临床疗效和安全性。方法:65例脑梗死急性期合并认知功能障碍的患者,随机分为奥拉西坦组38例,在常规治疗的基础上给予奥拉西坦注射液4.0g/d,共21天;吡拉西坦组27例,在常规治疗的基础上给予吡拉西坦给予4.0g/d,共21天。观察用药前后简易精神状况检查量表(MMSE)评分、事件相关电位P300的改善程度。结果:奥拉西坦和吡拉西坦均可改善脑梗死急性期MMSE评分、P300潜伏期和波幅,但奥拉西坦改善程度更为显著。结论:奥拉西坦可用于脑梗死急性期认知功能障碍的治疗,且疗效优于吡拉西坦。
Objective：To evaluate the effect of Oxiracetam on improving cognitive impairment in acute cerebral infarction, and assess its clinical efficacy and safety.Methods：Based on the routine treatment,65 cases of acute cerebral infarction and cognitive dysfunction were randomly divided into oxiracetarn group in which 38 cases were administrated oxiracetam injection 4.0g/d for 21days,and Piracetam group in which 27 patients were given piracetam at the dose of 4.0g/d for 21 days.The simple mental state examination questionnaire （MMSE） score and improvement of event-related potential P300 before and after administration were observed.Results：Oxiracetam and piracetam can improve the MMSE score at acute stage.P300 latency and amplitude.but even more significant improvement was obtained by Oxiracetam.Conelusion： Oxiracetam can be used for treatment of cognitive dysfunction in acute cerebral infarction,and more effective than piracetam.
出处
《中国医药导刊》
2010年第9期1560-1561,共2页
Chinese Journal of Medicinal Guide
关键词
脑梗死
急性期
认知功能障碍
奥拉西坦
Cerebral infarction
Acute stage
Cognitive dysfunction
Oxiracetam
