摘要
目的:评价奥拉西坦对脑梗死急性期认知功能障碍的改善作用,评估其临床疗效和安全性。方法:65例脑梗死急性期合并认知功能障碍的患者,随机分为奥拉西坦组38例,在常规治疗的基础上给予奥拉西坦注射液4.0g/d,共21天;吡拉西坦组27例,在常规治疗的基础上给予吡拉西坦给予4.0g/d,共21天。观察用药前后简易精神状况检查量表(MMSE)评分、事件相关电位P300的改善程度。结果:奥拉西坦和吡拉西坦均可改善脑梗死急性期MMSE评分、P300潜伏期和波幅,但奥拉西坦改善程度更为显著。结论:奥拉西坦可用于脑梗死急性期认知功能障碍的治疗,且疗效优于吡拉西坦。
Objective:To evaluate the effect of Oxiracetam on improving cognitive impairment in acute cerebral infarction, and assess its clinical efficacy and safety.Methods:Based on the routine treatment,65 cases of acute cerebral infarction and cognitive dysfunction were randomly divided into oxiracetarn group in which 38 cases were administrated oxiracetam injection 4.0g/d for 21days,and Piracetam group in which 27 patients were given piracetam at the dose of 4.0g/d for 21 days.The simple mental state examination questionnaire (MMSE) score and improvement of event-related potential P300 before and after administration were observed.Results:Oxiracetam and piracetam can improve the MMSE score at acute stage.P300 latency and amplitude.but even more significant improvement was obtained by Oxiracetam.Conelusion: Oxiracetam can be used for treatment of cognitive dysfunction in acute cerebral infarction,and more effective than piracetam.
出处
《中国医药导刊》
2010年第9期1560-1561,共2页
Chinese Journal of Medicinal Guide
关键词
脑梗死
急性期
认知功能障碍
奥拉西坦
Cerebral infarction
Acute stage
Cognitive dysfunction
Oxiracetam