大理白族29例系统性红斑狼疮患者自身抗体检测结果分析

Dali Bai 29 Cases of Patients with Systemic Lupus Erythematosus Autoantibody Analysis of Test Results

目的:通过对大理白族系统性红斑狼疮(SLE)患者中各种自身抗体的综合分析评价,为SLE患者早期诊断和治疗提供实验室依据。方法:采用间接免疫荧光法检测29例大理白族系统性红斑狼疮患者血清中抗核抗体(ANA),抗双链DNA抗体(抗ds-DNA);免疫印迹法检测抗核抗体谱(ANA16项),以51例抗核抗体谱结果阳性的其它病例作为对照。结果:抗ds-DNA和抗sm仅出现于SLE患者血清中;抗nRNP抗体在SLE中的阳性率明显高于其他自身免疫病患者;有三例治疗后复检的SLE患者抗核抗体谱结果阴性。结论:SLE患者女性为主;SLE患者血清中可出现多种自身抗体,但抗ds-DNA和抗sm是SLE的特征性抗体;间接免疫荧光法检测抗ds-DNA抗体敏感性比免疫印迹法高;SLE患者治疗缓解期自身抗体可转为阴性。

Objective：Dali Bai systemic lupus erythematosus （SLE） autoantibodies in patients with a variety of comprehensive analysis and evaluation for early diagnosis and treatment of SLE patients providing laboratory basis.Methods：Indirect immunofluorescence assay 29 cases of Dali Bai serum of patients with systemic lupus erythematosus anti-nuclear antibody （ANA）,anti-double-stranded DNA antibodies （anti- ds-DNA）;Western blot detection of anti-nuclear antibody spectrum （ANAl 6 items）,to 51 cases of anti-nuclear antibody-positive spectral results of other cases as controls.Results：Anti-ds-DNA and anti-S m is only seen in the serum of patients with SLE;anti-nRNP antibody positive rate in SLE was significantly higher than in other autoimmune disease; the three cases of SLE patients after treatment re-examination of the results of anti-nuclear antibody spectrum negative.Conclusion：SLE patients with female-dominated;SLE patients with a variety of serum autoantibodies may appear,but the anti-ds-DNA and anti-S m is the characteristic SLE antibodies; indirect immunofluorescence assay detection of anti-ds- DNA antibody-sensitive than Western blot France Gao;SLE autoantibodies in patients in remission may be turned intonegative.