冠心病患者血浆组织因子及组织因子途径抑制物变化分析

Analyze on the Plasma Tissue Factor and Changes of Tissue Factor Pathwaylnhibitor Levels in Plasma in Coronary Heart Disease

目的:探讨冠心病患者血浆组织因子及组织因子途径抑制物变化。方法:用酶联免疫吸附试验法测定48例冠心病患者其中稳定型心绞痛(SAP)患者16例;不稳定型心绞痛(UAP)患者16例;心肌梗死(AMI)患者16例;正常健康(NC)组11例血浆TF、TFPI。结果:AMI组血浆TF活性及TFPI含量与NC组、SAP组比较显著升高(P<0.01);AMI组与UAP组比较血浆TF活性和TFPI含量显著升高(P<0.05);AMI组的TF比UAP组显著升高(P<0.05);TFPI含量AMI组与UAP组比较两者差异无统计学意义(P>0.05)。结论:UAP、AMI发病期间存在异常增高的TFPI浓度TF活性增高,UAP、AMI的发病与斑块不稳定及血栓形成有关,TFPI可能是冠心病内皮细胞损伤后凝血的标志之一。

Objective： To probe into the plasma tissue factor and changes of tissue factor pathway inhibitor levels in plasma in coronary heart disease.Methods：TF and TFPI were determined by ELISA in 48 patients with coronary heart disease, in which 16 patients with stable angina pectofis （SAP group）, 16 patients with unstable angina pectoris （UAP group）, 16 patients with acute myocardial infarction （AMI group）, and 11 healthy controls （NC group）. Results：Compared with NC group and SAP group, the TF and TFPI in AMI group were significantly higher （P〈0.01）; Compared with UAP group, the TF and TFPI in AMI group were significantly higher （P〈0.05）; but not influenced in the comparison between AMI group and UAP group （P〈0.05）. Conelusions：TFPI in UAP and AMI group increased abnormally and TF activity was increased in occurent stage. It relates to unstable plaques and thrombosis. TFPI may be one sign that blood coagulation after endothelial cells damages.