比索洛尔、稳心颗粒对心肌病室性心律失常和心率变异性的影响

Effect of bisoprolol、wenxin granules on ventricular arrhythmias and heart rate variability in patients with cardiomyopathy

目的观察比索洛尔、稳心颗粒对心肌病患者的室性心律失常和心率变异性的影响。方法 80例心肌病患者在常规抗心衰药物治疗的基础上,随机分成两组,比索洛尔组每日口服比索洛尔1.25～10mg,稳心颗粒9g,3次/d。对照组口服安慰剂,疗程9个月,观察治疗前后室性心律失常和心率变异性的变化。结果比索洛尔组室性心律失常明显减少,心率变异性参数显著改善。结论长期使用比索洛尔、稳心颗粒可降低心肌病恶性室性心律失常的发生,改善心率变异性。

Objective To observe the effect of bisoprlolo、wenxin Granules on ventricular arrhythmias and heart rate variabilitve in patients with Cardiomyopathy. Methods Eighty patients with Cardiomyopathy taken conventional digitals,diuretics,vasodilators therapy were randomly assigned to receive bisoprolol（ 1. 25-10 mg/d） ,wenxin Granules（ 9 g,three/d） or placebo for 9 months,ventricular arrhythmias,index of heart rate vari-ability were observed. Results Compared to the control group,the occurrence of ventricular arrhythmias in biso-prolol group decreased significantly,with improvement of index of heart rate variability. Conclusion Long term administration of Bisoprolol and wenxin Granules can reduce malignant ventricular arrhythmias,improve heart rate variability in patients with Cardiomyopathy.