摘要
目的探讨巨噬细胞移动抑制因子(MIF)和血管内皮生长因子(VEGF)在子宫内膜异位症(Ems)组织中的表达情况及其两者的相关性。方法应用免疫组织化学技术对50例EMs组织中的MIF和VEGF蛋白的表达情况进行研究。结果 MIF在Ems中异位内膜的表达明显高于在位内膜(P<0.05),在位内膜中的表达明显高于正常对照内膜(P<0.05);VEGF在Ems中异位内膜的表达同样明显高于在位内膜(P<0.05),在位内膜中的表达高于正常对照内膜(P<0.05);MIF和VEGF表达呈正相关。结论 MIF和VEGF在异位内膜中的表达呈明显的正相关,提示MIF与VEGF协同促进异位内膜的生长。
Objective To discuss the expression of macrophage migration inhibitory factor（MIF） and vascular endothelial growth factor（VEGF） in endometriosis（Ems） tissues and the correlation between MIF and VEGF.Methods A research is conducted on the protein expressions of MIF and VEGF in 50 cases of EMs organizations with the immunohistochemis-trical SP method.Results The expression of MIF in the eutopic endometrial endometrial was significantly higher than that in the ectopic endometria in endometriosis（P0.05）;the expression of MIF in the ectopic endometria in endometriosis was higher than that in the normal endometrium（P0.05）;the expression of VEGF in the eutopic endometrial was also significantly higher than that in the ectopic endometria in endometriosis（P0.05）;the expression of MIF in the ectopic endometria in endometriosis was higher than that in the normal endometrium（P0.05）;so there was a positively correlation between MIF and VEGF.Conclusion The expression of MIF and VEGF in ectopic endometrial was significantly positively correlated,suggesting that MIF and VEGF playing an important role in the growth of ectopic endom.
出处
《中国实验诊断学》
北大核心
2010年第9期1405-1407,共3页
Chinese Journal of Laboratory Diagnosis
