中药内外兼治配合依那西普治疗类风湿性关节炎疗效观察

Observation of TCM Internal and External with Etanercept on the treatment of Rheumatoid Arthritis

目的:观察中药内外兼治配合依那西普治疗类风湿性关节炎(RA)的疗效及安全性。方法:57例随机分为治疗组25例和对照组32例。对照组应用依那西普,每次剂量为25mg,皮下注射,每周2次;治疗组在对照组治疗的基础上采用口服中药配合外敷中药疗法。两组疗程均为6个月。治疗前后监测临床疗效指标的变化及药物的不良反应。结果:治疗组总有效率显著高于对照组(P<0.05);在关节疼痛数、关节压痛积分、关节肿胀积分、晨僵时间及20m步行时间等方面均与用药前比较有显著改善(P<0.05或P<0.01);治疗组不良反应发生率显著低于对照组(P<0.05)。结论:中药内外兼治配合依那西普治疗RA疗效优于单用依那西普,且不良反应少而轻微,安全性好。

Objective：To observe the efficacy and safety of TCM Internal and External with Etanercept on the treatment of rheumatoid arthritis（ RA）. Methods：57 patients were randomly divided into treatment group（ 25 cases ） and the control group（ 32 cases）. The control group received etanercept,each dose of 25mg,subcutaneously 2 times per week; the treatment group received oral TCM medicine and external application of Chinese medicine on the basis of therapy in the control group. Group 2 course of treatment for 6 months. Before and after treatment to monitor changes in indicators of clinical efficacy and adverse drug reactions. Results：The treatment group was significantly higher than The control group at the total effective rate（ P 0. 05） ; The treatment group after treatment compared with pre-treatment significantly improved efficacy in the number of joint pain,joint tenderness score,joint swelling score,morning stiffness time and 20m walking time,and so on（ P 0. 05 or P 0. 01） ; The treatment group was significantly lower than the control group at the incidence of adverse reactions（ P 0. 05）. Conclusion：TCM Internal and External with Etanercept on the treatment of RA was more effective than etanercept alone,and few and mild adverse reactions,safety is good.