1Piccirillo CA,Thornton AM.Cornerstone of eripheral tolerance:naturally occurring CD+4 CD+25 regulatory T cells.Trends Immunol,2004,25:374-380.
2Fehervari Z,Sakaguchi S.CD4+Tregs and immune control.J Clin Invest,2004,114:1209-1217.
3Hori S,Nomura T,Sakaguchi S.Control of regulatory T cell development by the transcription factor Foxp 3.Science,2003,299:1057-1061.
4Pasare,Chandrashekhar,Medzhitov,et al.Toll-like receptors:balancing host resistance with immune tolerance.J Current Opinion in Immunology,2003,15:677-682.
5Crellin NK,Garciaa RV,HadisfarO,et al.Human CD4+ T cells espress TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FoxP3 in CD+4 CD+25 T regulatory cells.J Immunol,2005,175:8051-8059.
6Pen G,Guo Z,Kiniva Y,et al.Toll-like rexeptor 8-mediated reversal of CD4+ regulatory T Cell funxtion.Science,2005,309:1380-1384.
7Chiffoleau E,Heslan JM,Heslan M,et al.TLR9 ligand enhances proliferation of rat CD4+ T cell and modurlates suppressive activity mediated by CD+4 CD+25 T cell.Int Immunol,2007,19:193-201.
8Nakamurak D,Kitani A,Straber W.Cell contact dependent immunosuppression by CD+4 CD+25 regulatory T cells is mediated by cell surface bound transforming growth factor.J Expmed,2001,194:629-644.
9Setaguchi R,Hori S,Takahashi T,et al.Homeostatic maintenance of natural Foxp3+ CD+4 CD+25 regulatory T cells by interleukin IL-2 and induction of autoimmune,disease by IL-2 neutralization.Jexp Med,2005,201:723-735.
10Shimizu J,Yamazaki S,Takahashi T,et al.Stimulation of CD25 (+) CD4 (+) regulatory T cells through GITR breaks immunological self-tolerance.Nat Immunol,2002,3:135-142.
