岩黄连总碱对小鼠急性化学性肝损伤的保护作用研究

Study of hepatoprotective effect of the total alkaloids from Corydalis saxicola bunting of the acute chemical hepatic injury model mice

目的:研究岩黄连总碱对CCl4所致小鼠急性肝损伤的保护作用。方法:腹腔注射给予CCl4致小鼠急性肝损伤,通过灌胃给药观察岩黄连总碱对其保护作用。结果:岩黄连总碱可明显降低CCl4因素所致急性肝损伤小鼠血清AST、ALT的含量。结论:岩黄连总碱对CCl4所致小鼠急性肝损伤具有保护作用。

Objective： To study the protective effect of the total alkaloids from Corydalis saxicola bunting of the acute hepatic injury model mice caused by carbon tetrachloride.Methods： The protective effect of the total alkaloids from Corydalis saxicola bunting by intragastric administration against peritoneal injection CCl4-induced hepatic injury in mice were investigated. Results： The contents of serum transaminases（ALT and AST） of medication administration team compare with model team was degraded. Conclusion： The results indicate that the CCl4-induced hepatic injury of mouse was protected significantly.