埃索美拉唑联合莫沙必利治疗胃食管反流病的临床观察

Clinical observation of gastroesophageal reflux disease treated by esomeprazole combined with mosapride

目的探讨埃索美拉唑联合莫沙必利治疗胃食管反流病的效果。方法 88例胃食管反流患者随机分为治疗组48例(埃索美拉唑联合莫沙必利)及对照组40例(奥美拉唑联合莫沙必利),分别于治疗4、8周后观察患者症状缓解情况及治疗有效率。结果治疗4、8周后治疗组患者的症状缓解情况显著高于对照组(P<0.05),治疗组有效率93.7%显著高于对照组77.5%(P<0.05)。结论埃索美拉唑联合莫沙必利是治疗胃食管反流病的有效方法。

Objective To investigate the curative effect of gastroesophageal reflux disease treated by esomeprazole combined with mosapride.Methods Eighty-eight patients with GERD were randomly divided into two groups：48 patients were treated by esomeprazole combined with mosapride,40 patients were treated by omeprazole combined with mosapride.Major symptoms were evaluated four weeks and eight weeks after treatment.The cure rate was evaluated eight weeks after treatment.Results Major symptoms in the group treated by esomeprazole combined with mosapride were alleviated after treatment for four and eight weeks.The effective rate of the group treated by esomeprazole combined with mosapride（93.7%） was higher than that of the group treated by omeprazole combined with mosapride（77.5%）（P0.05）.Conclusion Esomeprazole combined with mosapride is very effective in treatment of GERD.