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B7-CD_(28)/CTLA-4在胃癌患者中的表达及意义 被引量：2

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摘要 目的观察胃癌患者外周血中CD2+8、细胞毒性T淋巴细胞相关抗原-4(CTLA-4)(CD152)+T细胞和癌组织细胞表面B7表达水平,以进一步探讨肿瘤的免疫逃逸机制。方法研究对象包括同期手术治疗的胃癌患者(胃癌组)36例、胃炎及胃溃疡患者10例(胃良性疾病组)、健康查体者26例(对照组),采用流式细胞术检测三组外周血中CD3+、CD4+、CD8+、CD2+8、CTLA-4(CD152)+T细胞水平,检测前两组胃组织细胞B7分子表达水平。结果胃癌组外周血CD2+8T细胞水平显著低于其余两组(P<0.01)、CTLA-4(CD152)+T细胞水平显著高于其余两组(P<0.01);胃组织细胞B7-1(CD80)、B7-2(CD86)表达水平胃癌组显著低于对照组(P<0.01)。结论胃癌患者存在B7-CD28/CTLA-4共刺激通路异常,此可能为影响T细胞有效清除肿瘤细胞、从而使肿瘤逃避机体免疫监视的机制之一。
作者 迟小伟 刘杰
机构地区 山东中医药大学附属医院 济南市中心医院
出处 《山东医药》 CAS 北大核心 2010年第35期33-34,共2页 Shandong Medical Journal
关键词 胃肿瘤 胃癌 共刺激分子 CD28 细胞毒性T淋巴细胞相关抗原-4
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献6

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共引文献6

同被引文献26

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山东医药
2010年 第35期

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