注射用头孢孟多酯钠与木糖醇注射液配伍稳定性考察

Study on Stability of Compatibility of Cefamandole Nafate for Injection with Xylitol Injection

目的观察注射用头孢孟多酯钠与木糖醇注射液配伍的稳定性。方法室温（25℃）下,将注射用头孢孟多酯钠分别与5%和10%木糖醇注射液配伍,于0、1、2、4、6、8、24 h取样,采用紫外分光光度法测定主药吸光度值的变化以确定相对含量变化,同时测定pH值。结果注射用头孢孟多酯钠与5%和10%木糖醇注射液在室温（25℃）下配伍,0~8 h内其外观、pH值及含量无明显变化。结论本试验提示头孢孟多酯钠与木糖醇注射液配伍较为稳定,其试验结果可供临床配伍使用参考。

Objective To observe the stability of compatibility of cefamandole nafate for injection with xylitol injection.Methods The samples of the complexes were collected at 0,1,2,4,6,8,24 h after mixing cefamandole nafate with 5% or 10% xylitol injection at 25℃.The variations of absorbance values of cefamandole nafate for injection were detected by UV-spectrophotometry in order to define the contents,and pH values were also detected.Results Compatibility of cefamandole nafate for injection with 5% and 10% xylitol injection showed no significant changes of external appearance,pH values and contents within 0~8 h at RT（25℃）.Conclusion Cefamandole nafate for injection has good stability in xylitol injection,and the result can provide reference for clinical compatibility of cefamandole nafate for injection.