索拉非尼药物不良反应临床特征分析与防治

The Clinical Characteristic and Prevention of ADRs Induced by Sorafenib

目的分析小分子靶向抗肿瘤药物甲苯磺酸索拉非尼引起的不良反应临床特征、危险因素和防治措施,为临床合理用药提供依据。方法对40例索拉非尼引起的不良反应患者一般情况、原患疾病、用法用量、合并用药、不良反应发生时间、临床表现、涉及的器官或系统、严重程度及疾病转归进行统计分析。结果不良反应的主要表现为腹泻、恶心、呕吐、疲劳、手足皮肤反应及高血压,发生率与用药剂量密切相关。结论加强索拉非尼的用药监测,确保临床用药安全。

Objective To analyse the characteristics,relevant factors and the prevention of the adverse drug reaction induced by sorafenib.Methods 40 cases ADR reports collected in our hospital were analyzed retrospectively in respect of patients＇ age and sex,clinical manifestations,usage and dosage,occurrance time of ADR,manifestation of ADR,ADR-involved organs or systems,order of severity and prognosis of disease.Results Our results showed that the incidence of ADRs were closely related to drug dosage.The chief manifestations included diarrhoea,nausea,vomiting,fatigue,hand-foot skin reaction,hypertention and so on.Conclusion Sorafenib is new type targeted antitumor drug,the ADR induced by sorafenib should be highly emphasized in order to ensure the safety of drug clinical usage.