小动物脑功能磁共振成像研究进展

Current status of small animal brain functional MRI

本文主要介绍血氧水平依赖的小动物脑功能磁共振成像的研究条件、范围和研究方法,并简述小动物在发展非血氧水平依赖功能磁共振技术中所起的作用。尽管小动物脑磁共振成像研究受到麻醉等条件的限制,这项研究已经在神经科学及神经药理学范围作出了诸多贡献,并受到越来越多的重视。

This review describes the present status of the technological development and neuroscience application of BOLD-fMRI on small animals. Also, a using of small animals in exploring bloodless fMRI techniques is briefly introduced as well. Extremely high magnet is essential and small animals require anesthesia during fMRI data acquisition. In spite of such limitations, impressive contributions having been made by small animal fMRI studies in neuroscience and neuropharmacology fields have gained great attention in brain research community to realize its potential.