鼠神经生长因子联合单唾液酸神经节苷酯治疗周围神经损伤的疗效观察

Observation of effects of mouse nerve growth factor combined with a single sialic acid gangliosides on the peripheral nerve injury

目的探讨鼠神经生长因子联合单唾液酸神经节苷酯治疗周围神经损伤的疗效。方法 60例桡神经损伤患者,随机分为鼠神经生长因子联合单唾液酸神经节苷酯组(联合组)和鼠神经生长因子组(单用组),每组均为30例。联合组应用鼠神经生长因子20μg+0.9%氯化钠2ml溶解,肌注,1次/d和5%葡萄糖250ml+单唾液酸神经节苷酯40mg,静滴,1次/d联合治疗共1个疗程(30d),鼠神经生长因子组单纯应用鼠神经生长因子20μg+0.9%氯化钠2ml溶解,肌注,1次/d共治疗1个疗程(30d);30d后,通过临床表现和肌电图检查结果,分析疗效。结果联合组疗效明显优于单用组,差异有统计学意义(P<0.05)。结论鼠神经生长因子与单唾液酸神经节苷酯治疗周围神经损伤中具有协同作用,值得临床推广。

Objective To observe the curative effects of mouse nerve growth factor combined with a single sialic acid gangliosides to peripheral nerve injury.Methods The cases of standard correspond in 60 cases with peripheral nerve injury randomly divided into Mouse nerve growth factor combined with a single sialic acid gangliosides group （combination group）,Mouse nerve growth factor group（NGF group）. 30 cases in each group.Combination group using NGF 20μg ＋0.9% sodium chloride solution 2ml,im and 5% glucose 250ml＋single sialic acid gangliosides 40mg,ivbydrip, once every day,A course of treatment （30d）, NGF group were using a mouse nerve growth factor 20μg ＋0.9% sodium chloride solution 2ml,im,once every day, A course of treatment （30d））, observe the curative effects through the result of clinical performance and muscle electronystagmographys.Results The results were combination group better than NGF group,the difference was statistically significant （P0.05）.Conclusion Mouse nerve growth factor and a single sialic acid gangliosides to peripheral nerve injury has a assisted effect, worthy of promotion.