甜梦胶囊对慢性淋巴细胞性甲状腺炎TGA、TMA的影响

Effect of Tian Meng Capsule Treatment on Serum TGA,TMA Levels in Patients with Hashimoto's Disease

目的:探讨甜梦胶囊对慢性淋巴细胞性甲状腺炎(CLTD)患者抗甲状腺球蛋白抗体(TGA)及抗甲状腺微粒体抗体(TMA)的作用影响。方法:60例CLTD者随机分为观察治疗组(30例)及常规治疗组(30例),两组伴甲亢或甲减者分别采用抗甲状腺药物或甲状腺素等常规治疗,观察治疗组在常规治疗基础上联合甜梦胶囊并用。以放射免疫分析患者治疗前后及30例正常人的血清TGA、TMA水平。结果:观察治疗组临床疗效显著高于常规治疗组(P<0.05与P<0.01),治疗前后两种抗体下降水平也具有重要的统计学意义(P<0.01)。结论:甜梦胶囊对CLTD疗效肯定,TGA、TMA浓度降低可能是其提高机体免疫力的药理作用机制之一。

Objective To study the effect of tian meng capsule treatment on the serum levels of TGA,TMA in patients with chronic lymphocytic thyroiditis（CLTD or Hashimoto＇s disease）.Methods Serum TGA and TMA levels were determined with RIA both before and after treatment for 3 months in ① 30 patients treated with conventional drugs ② 30 patients treated with conventional drugs plus tian meng capsule（a traditional chinese medicine preparation #2,tid）and ③ once in 30 controls.Results Before treatment,the serum TGA and TMA levels in all the patients were significantly,higher than those in controls.After 3 months＇ treatment,serum TGA and TMA levels in all the patients dropped,but the levels in the patients treated with additional tian meng capsule were significantly lower than those in patients without tian meng capoule treatment.Moreover,76.7% of the patients with tian meng capsule treatment had their serum TGA and TMA levels decreased over 30%,four patients even had the serum levels became normal.Conclusion tian meng capsule treatment is very effective in lowering serum TGA and TMA levels in patients with Hashimoto＇s disease.