AP患者的炎性介体(IL-6和IL-8)和血脂水平的临床分析

Study on the Serum Levels of Imflammatory Cytokines IL-6,IL-8 and Lipid Profile in Patients with Acute Pancreatitis

目的:为了探讨114例急性胰腺炎(AP)患者血清IL-6、IL-8和血脂分析早期诊断和治疗的临床意义。方法:EIA测定了114例AP患者的血清IL-6和IL-8水平,其中急性重症胰腺炎(SAP)46例,中轻型急性胰腺炎(MAP)68例;生化法测定了114例AP患者的血脂水平,包括总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,并与治疗前后和60例正常对照组进行了比较性分析。结果:114例AP患者其中46例SAP患者和68例MAP患者血清IL-6和IL-8水平较之60例正常对照组均明显增高(P均<0.01),SAP和MAP患者(7～10)d治疗后,IL-6和IL-8水平较治疗前明显降低(P<0.01),但较正常对照组仍明显增高(P<0.01)。血脂分析表明,114例AP患者中血脂4项水平治疗前较60例正常对照组均明显增高(P<0.05～0.01),经(7～10)d治疗后,46例SAP患者的血脂水平较正常对照组仍明显增高(P<0.05～0.01);而68例MAP患者的血脂水平恢复至正常水平(P>0.05)。结论:AP患者中血清IL-6、IL-8水平和血脂分析不仅是急诊早期诊断的良好指标,而且是治疗前后随访的有效工具。

Objective To study the clinical significance of changes of serum levels of IL-6,IL-8 and lipid profile in patients with acute pancreatitis.Methods Serum levels of IL-6,IL-8（with EIA）and lipid profile（with biochemistry）were determined in 114 patients with acute pancreatitis（severe cases,n=46,moderate and mild cases,n=68）both before and after treatment（7~10d）and 60 controls.Results The serum levels of IL-6 and IL-8 in the 114 patients before treatment were significantly higher than those in the controls（both P〈0.01）.After treatment,the cytokines levels were dropped significantly（vs before treatment,P〈0.01）,but still remained significantly higher than those in controls（P〈0.01）.Lipid profile study（TC,TG,HDL-C,LDL-C）showed significantly higher values in the pancreatitis patients than the levels in controls（P〈0.05 or P〈0.01）before treatment.After treatment,the lipid profiles were much corrected.However,only in moderate and mild cases,the values were approaching those in controls（P〈0.05）,while in severe cases,the values were still significantly higher than those in controls（P〈0.05~P〈0.01）.Conclusion Serum IL-6,IL-8 levels and lipid profile were closely related to the disease process in patients with acute pancreatitis.