宫颈微小偏离型腺癌5例临床病理学观察

Minimal deviation adenocarcinoma of cervix:a clinicopathologic analysis of 5 cases

目的:提高宫颈微小偏离型腺癌的病理学认识。方法:对5例宫颈微小偏离型腺癌患者的临床及病理资料进行分析。结果:患者平均年龄50.4岁。临床症状为不规则阴道出血、水样白带或下腹痛。肿瘤主要由呈浸润性生长的分化较好的粘液性腺体组成。腺体分布大多密集、紊乱,呈多种形状。瘤细胞可有轻度不典型增生。结论:宫颈微小偏离型腺癌是一种少见的高分化粘液腺癌,分化程度高,容易漏诊。在病理学诊断时要综合考虑患者的临床表现、症状和体征,免疫组化具有一定的辅助诊断价值。

Objective：To characterize clinicopathological features of minimal deviation denocarcinoma（MDAC） and enhance the knowledge of the disease.Methods：5 cases of MDAC were studied by analyzing the clinical and pathological data.Results：The average age of the patients was 50.4 years.The clinical symptoms were vaginal bleeding irregularly,watery leucorrhea or hypogastralgia.Histologically,the tumors were composed of well-differentiated mucous gland with infiltrated growth.The shape of tumor glands was various and their distribution was to concentrating and confusing in most cases.There was light atypical hyperplasia within some tumor cells.Conclusions：MDAC is a rare well-differentiated mucous denocarcinoma.In making diagnosis of MDAC the clinical manifestations,symptoms and physical signs should be taken into account comprehensively,in order to increase the accuracy of diagnosis and avoid missed diagnosis.Furthermore,the immunohistochemistry has some adjuvant values in confirming the diagnosis of MDAC.