C型利钠肽和长骨生长

C-type natriuretic peptide and long bone growth

C型利钠肽（CNP）是长骨生长重要的局部调节因子,与受体NPR-B结合后催化cGMP的合成,激活下游因子调节长骨生长.CNP信号系统的调节机制尚未完全阐明,目前已知CNP信号系统与成纤维细胞生长因子受体3（FGFR-3）信号通路存在交联对话.NPR-B基因突变的杂合子可能是引起特发性矮小的原因之一.CNP可作为线性生长的生物标记,用于生长监测及生长障碍性疾病的诊断和治疗.对CNP信号系统与长骨生长关系的深入研究,有助于为今后骨骼发育障碍疾病的药物治疗开辟新途径.

C-type natriuretic peptide （CNP） is an important local regulator of long bone growth. It catalyzes the synthesis of cGMP after binding to its receptor natriuretic peptide receptor-B （NPR-B） ,and regulates long bone growth by activating downstream factors. Though the mechanism of the regulation of CNP signaling remains unclear, it has been demonstrated that CNP signaling has a ＂cross-talk＂ with the fibroblast growth factor receptor 3 pathway in cartilate.Heterozygous NPR-B mutations maybe one of the molecular basis of idiopathic short stature. CNP can be used as a biological marker of linear growth, with great importance in growth monitoring, diagnosis and treatment of growth disorders.The research on the mechanism of CNP signaling system in endochondral ossification will contribute to a new medication for bone development disorders in the future.