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下丘脑Kisspeptin表达与青春期发育的关系 被引量：2

Expression of kisspeptin in hypothalamus and the relationship between kisspeptin and puberty
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摘要 青春期启动始于下丘脑促性腺激素释放激素（GnRH）分泌的提高.Kisspeptin/G蛋白耦联受体（GPR 54或KISSIR）信号通路是最近发现能促进GnRH分泌和正常青春期启动的关键因素.KISS1表达定位于下丘脑的特定区域,在动情周期中受性激素调节,Kisspeptin传递性激素的反馈信号至GnRH细胞,特别是正反馈信号可以引起排卵前的GnRH/黄体生成素分泌.Kisspetin与位于下丘脑GnRH神经元上的受体KISS1R相互作用,导致GnRH脉冲性释放和青春期启动. The priming of puberty is date from the increase of the secretion of hypothalamic gonadotropin-releasing hormone （GnRH）. Recently, Kisspeptins/ GPR54 signaling were found critical to promote the secretion of GnRH and the onset of puberty. KISS1 expresses in special area of hypothalamus and is regulated by sex steroids in the estrous cycle. Kisspeptins transitive steroid feedback signals to GnRH ceils, especially the positive feedback signal which causes preovulatory GnRH / LH secretion. Kisspeptins bind KISS1R in the hypothalamic GnRH neurons and evoke the release of GnRH and the onset of puberty.
作者 丁海珍(综述) 于宝生(审校)
机构地区 南京医科大学第二附属医院小儿内分泌科
出处 《国际儿科学杂志》 2010年第5期531-533,共3页 International Journal of Pediatrics
关键词 青春期 促性腺激素释放激素 G蛋白耦联受体 KISSPEPTIN Puberty Gonadotrophin-releasing hormone G protein-coupled receptor Kisspeptin
分类号 R335.1 [医药卫生—人体生理学]
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参考文献20

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  • 5Ramaswamy S,Gibbs RB,Plant TM.Studies of the localisation of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta) and the effect of kisspeptin on the release of non-gonadotropic pituitary Hormones.J Neuroendocrinol,2009,21 (10):795-804.
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同被引文献34

  • 1王雪松,张才田,居晓斌,张朝晖,丁贵鹏,陈子庆,苏恩本,崔毓桂.大鼠下丘脑KiSS-1与GnRH mRNA的表达[J].中华男科学杂志,2007,13(4):315-319. 被引量：4
  • 2Lee D K,Nguyen T,O'Neill G P. Discovery of a receptor related to the galanin receptors[J].FEBS Letters,1999,(01):103-107.doi:10.1016/S0014-5793(99)00009-5.
  • 3Kaiser U B,Kuohung W. GPR54 and kiss-l:Role in the regulation of puberty and reproduction[J].Reviews in Endocrine and Metabolic Disorders,2006,(04):257-263.
  • 4Navarro V M,Castellano J M,Garcia Galiano D. Neuroendocrine factors in the initiation of puberty:The emergen role of kisspeptin[J].Reviews in Endocrine and Metabolic Disorders,2007,(01):11-20.
  • 5Muir A I,Chamberlain L,Elshourbagy N A. AXORl2,a novel human G protein coupled receptor,activated by the peptide kiss-1[J].Biological Chemistry,2001,(31):2896928975.
  • 6Roa J,Aguilar E,Dieguez C. New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function[J].Frontiers in Neuroendocrinology,2008,(01):48-69.
  • 7Clarkson J,Herbison A E. Postnatal development of kisspeptin neurons in mouse hypothalamus;sexual dimorphism and projections to gonadotrop in-releasing hormone neurons[J].Endocrinology,2006,(12):5817-5825.
  • 8Ramaswamy S,Gibbs R B,Plant T M. Studies of the localisation of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta) and the effect of kisspeptin on the release of non-gonadotropic pituitary hormones[J].Neuroendocrinology,2009,(10):795-804.
  • 9Gottsch M L,Cunningham M J,Smith J T. A role for kisspeptins in the regulation of gonadotrop in secretion in the mouse[J].Endocrinology,2004.4073-4077.
  • 10Colin J S,Bradley J W,Gregory S F. Neurons that co-localize aromatase-and kisspeptin-like immunoreactivity may regulate the HPG axis of the Mallard drake (Anas platyrhynchos)[J].Italian Journal of Psychology,2010.606-613.

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国际儿科学杂志
2010年 第5期

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