早期康复介入对急性脑梗死炎症反应的影响

Effect of Early Rehabilitation on Inflammatory Response after Acute Cerebral Infarction

目的观察早期康复治疗对急性脑梗死(ACI)患者的运动功能、血清超敏C-反应蛋白(hs-CRP)、白细胞介素-1(IL-1)和白细胞介素-6(IL-6)含量动态变化的影响。方法 160例ACI患者随机分为两组,康复组80例采用早期康复治疗和常规中西药物治疗,对照组80例仅采用常规中西药物治疗。测定两组患者治疗前和治疗后1、2、4、8周后外周血hs-CRP、IL-1和IL-6含量,用改良爱丁堡-斯堪的纳维亚脑卒中评定表(MESSS)进行神经功能评定。结果康复组治疗后4、8周时外周血hs-CRP、IL-1和IL-6水平低于对照组(P<0.05);MESSS评分明显低于对照组(P<0.01),康复组临床总有效率高于对照组(P<0.05)。结论早期康复干预可降低急性脑梗死患者患者血清hs-CRP、IL-1和IL-6水平,并降低临床神经功能缺损程度,提高临床疗效。

Objective To observe the effect of early rehabilitation on motor function,high-sensitivity C-reactive protein（hs-CRP）,interleukin-1（IL-1）and interleukin-6（IL-6）in patients with acute cerebral infarction（ACI）.Methods160 patients with ACI were randomly divided into rehabilitation group（n=80）and control group（n=80）,who accepted early rehabilitation and routine medicine or medicine only,respectively.They were assessed with modified Edinburgh-Scandinavian Stroke Scale（MESSS）and their peripheral level of hs-CRP,IL-1 and IL-6 were detected before and 1,2,4,and 8 weeks after treatment.Results4 and 8 weeks after treatment,the level of hs-CRP,IL-1 and IL-6 were lower in rehabilitation group than in control group（P〈0.05）,as well as the scores of the MESSS（P〈0.01）.The incidence of improvement is more in rehabilitation group than in control group（P〈0.05）.ConclusionEarly rehabilitation can reduce the expression of hs-CRP,IL-1 and IL-6,and improve the neurological function in patients with ACI.