摘要
目的探讨血液高凝状态恶性肿瘤患者经外周静脉置入中心静脉导管(PICC)同步抗凝治疗预防静脉血栓的效果。方法将60例血液高凝状态恶性肿瘤患者随机分为观察组和对照组各30例,对照组PICC置管期间按常规方法预防静脉血栓发生,观察组增加同步抗凝治疗即低分子肝素钠5000U皮下注射,1～2次/d,使用时间≤15d。结果观察组PICC置管后15d血小板计数显著低于对照组,未发生静脉血栓,PICC置管时间显著长于对照组(均P<0.01)。结论血液高凝状态恶性肿瘤患者PICC置管同步抗凝治疗可显著改善其血液高凝状态,预防静脉血栓形成,延长PICC置管时间,有利于患者顺利完成治疗。
Objective To explore the effect of synchronous anticoagulation on prevention of thrombosis in malignancy patients with hypercoagulability and PICC placement.Methods Sixty malignancy patients with hypercoagulability were placed PICC and rando-mized into two groups,with 30 cases in each group.Patients in control group were given conventional measures for preventing thrombosis,while participants in observation group were conducted synchronous anticoagulation that hypodermic injection of low molecular weight heparin （5 000 U） was administered additionally for less than or equal to 15 days,with the frequency being 1-2 times per day.Results The platelet count in the observation group was significantly lower than that in the control group on the 15th day after PICC placement,and no thrombosis developed,the indwelling duration was significantly prolonged （P〈0.01 for all）.Conclusion Synchronous anticoagulation for malignancy patients with hypercoagulability and PICC placement can reduce hypercoa-gulability,prevent thrombosis and prolong indwelling duration of PICC.It can help patient complete treatment smoothly.
