西酞普兰与阿米替林对2型糖尿病伴抑郁患者血糖影响的对照研究

A case-control study of the affection of citalopram and amitriptyline on blood glucose in patients with depression and type 2 diabetes

目的:比较西酞普兰与阿米替林治疗2型糖尿病伴抑郁患者的疗效及对血糖的影响。方法:将60例2型糖尿病伴抑郁患者随机分为两组,分别给予西酞普兰和阿米替林治疗8周,采用汉密尔顿抑郁量表(HAMD,24项)评定疗效。测定血糖,采用放射免疫法测定皮质醇水平。结果:治疗8周后,西酞普兰组显效率70%,总有效率93.33%;阿米替林组分别为63.33%和83.33%,两组疗效比较无统计学差异(P>0.05)。西酞普兰组血糖、皮质醇水平较阿米替林组显著降低(P<0.01)。结论:西酞普兰对改善2型糖尿病伴抑郁患者的症状疗效显著,并且能控制血糖水平。

Objective：We aim to compare the efficacy and impact on blood sugar of citalopram and amitriptyline in the treatment of type 2 diabetes patients with depression.Methods：60 patients with type 2 diabetes and depression were randomly divided into two groups and were given citalopram and amitriptyline in the treatment of 8 weeks,using the Hamilton Depression Rating Scale（HAMD,24 items） evaluated.Glucose,with cortisol levels measured by radioimmunoassay.Results：After 8 weeks of treatment,effective rate citalopram group that were 70%,total effective rate was 93.33%;amitriptyline group were 63.33% and 83.33%,no significant difference between two groups（P〉 0.05）.However,the levels of blood glucose and cortisol of citalopram group were significantly decrease than those of amitriptyline group（P〈0.01）.Conclusion：Citalopram could improve the depressive symptoms in patients with type 2 diabetes mellitus,and could control blood glucose levels to some degree.