多囊卵巢综合征患者血清CRP与心血管危险因素关系研究

The study of serum high sensitive C-reactive protein and its relationship with cardiovascular risk factors in normoinsulinemic polycystic ovary patients

目的:研究非胰岛素抵抗且不伴有代谢综合征多囊卵巢综合征(PCOS)患者血清HS-CRP水平的变化,探讨HS-CRP与心血管危险因素之间的关系。方法:收集53例PCOS患者及47例正常女性的临床资料,检测血清内分泌激素、空腹血糖、空腹胰岛素、血脂和HS-CRP水平。结果:PCOS患者与对照组相比,WHR、睾酮、LDL、TC、TG和HS-CRP显著升高,HDL显著降低(P<0.05)。HS-CRP与BMI(r=0.45,P<0.0001)、WHR(r=0.68,P<0.0001)、LDL(r=0.63,P<0.0001)、TC(r=0.55,P<0.0001)和TG(r=0.34,P<0.0001)呈正相关,与HDL(r=-0.45,P<0.0001)呈负相关。HS-CRP与PCOS疾病状态之间也有相关性(r=0.71,P<0.001)。多元线性回归分析显示,BMI、WHR、LDL、HDL和PCOS疾病状态是影响HS-CRP独立因素。结论:血清胰岛素正常且不伴有胰岛素抵抗的PCOS患者血清HS-CRP水平升高,升高的HS-CRP与心血管危险因素相关。

Objective：To investigate serum high sensitive C-reactive protein（HS-CRP） levels in normoinsulinemic polycystic ovary syndrome（PCOS） patients without metabolic syndrome and whether there was any relationship between HS-CRP and other cardiovascular risk factors.Methods：53 normoinsulinemic PCOS patients without metabolic syndrome and 47 normoandrogenic ovulatory women were recruited.All the participants underwent standard clinical examinations and ultrasonograpic.Serum endocrine hormone,lipid,glucose,insulin and HS-CRP levels were measured.Results：PCOS patients had increased HS-CRP compared to the control group（P〈0.0001）.HS-CRP was positively correlated with body mass index（BMI）（r=0.45,P〈0.0001）,waist-to-hip ratio（WHR）（r=0.68,P〈0.0001）,LDL（r=0.63,P〈0.0001）,TC（r=0.55,P〈0.0001）and TG（r=0.34,P〈0.0001）,and negatively correlated with HDL（r=-0.45,P〈0.0001）.There was also a strong association between HS-CRP and PCOS status（r=0.71,P〈0.0001）in the study.Multivariate regression analysis demonstrated that BMI,WHR,LDL,HDL and PCOS status were also the independent variables that influenced HS-CRP in the overall group.Conclusion：Elevated HS-CRP was associated with cardiovascular risk factors in normoinsulinemic PCOS without metabolic syndrome.