丙戊酸镁缓释片合并舍曲林治疗难治性抑郁症对照研究

Comparative study between Magnesium valprote sustained release tablets with Sertraline in the treatment of refractory depression

目的:观察丙戊酸镁缓释片合并舍曲林治疗难治性抑郁症的疗效及安全性。方法:将50例难治性抑郁症患者随机分为研究组(丙戊酸镁缓释片合并舍曲林)30例和对照组(舍曲林)25例,观察8周。于治疗前及治疗每周末分别评定汉密尔顿抑郁量表(HAMD)和副反应量表(TESS),以HAMD减分率评定疗效。结果:研究组HAMD量表分于3周末显著下降,对照组HAMD量表分于4周末显著下降,研究组总有效率(70%)显著高于对照组(40%),P<0.05。结论:丙戊酸镁缓释片合并舍曲林治疗难治性抑郁症疗效确切。

Objective：To compare the efficacy and safety of magnesium valprote sustained release tablets and sertraline in treating refractory depression.Methods：50 patients with refracttory depression were divided into magnesium valprote sustained release tablets group（n=30） and sertraline group（n=20） with basic treatment of sertraline and followed for 8 weeks.Hamilton Depressive Scale（HAMD-17）and Treatment Emergent Symptom Scale（TESS） were used to evaluatethe efficacy and side effects at the point of week 1,weeks 2,weeks 4 and week 8.Results：After 8 weeks treatment,the total score of HAMD and the score ofeach factor reduced significantly in magnesium valprote sustained release tablets group,and the scores of trea-tment factors was significantly lower in magnesium valprote sustained release tablets group than those in sertraline group,side effects were fewer and milder.Conclusion：Magnesium valprote sustained release tablets with sertraline are an effective and safe drug in treating refractory depression.