急性冠脉综合征患者血浆N端B型脑钠肽前体与心脏血流动力学的相关性

The Relationship between Cardiac Hemodynamics and the Level of Plasma NT-proBNP in Patients with Acute Coronary Syndrome

目的：研究急性冠脉综合征（ACS）患者N端B型脑钠肽前体（NT-proBNP）与心脏血流动力学相关参数的相关性。方法：入选复旦大学附属中山医院心内科监护室ACS患者共37例,其中男性32例,女性5例,年龄36~84岁,对所有患者进行无创心脏血流动力学检测并收集NT-proBNP等血液指标数据。分析NT-proBNP与无创血流动力学各参数间的相关性,并采用多元逐步回归分析进行多因素分析。结果：NT-proBNP水平与左室射血分数、每搏输出量、心输出量、搏指数、心指数、血管最大扩张速度、左室射血期、收缩指数、收缩功能指数、电机械收缩期、左室舒张末期容积、主动脉顺应性、左室每搏作功、左室每分作功、搏功指数、心功能指数呈负相关,与射血前期/左室射血期、主外周阻力、血管最大再扩张速度呈正相关;多元回归显示,左室射血期及电机械收缩期在本研究中受其他因素影响比较大,故将其剔除。结论：ACS患者NT-proBNP水平与心脏血流动力学部分指标有相关性。

Objective：To explore the relationship between the plasma amino-terminal pro-brain natriuretic peptide （NT-proBNP） and cardiac hemodynamics.Methods： A total of 37 patients（aged 36-84,male 32） with acute coronary syndrome（ACS） from the cardiac medical intensive care unit of Zhongshan Hospital in Shanghai were enrolled.Each patient was tested by non-invasive cardiac hemodynamic monitor,meanwhile,NT-proBNP and other blood indicators were also measured.Spearman rank correlation test was used for the correlation analysis,and the multiple stepwise regression analysis was used for the multi-factor correlation analysis of the Blood parameters and hemodynamic parameters.Results： NT-proBNP levels correlated well with echocardiographic finding such as SV,CO,SVI,CI,EF,AMP C,IC,HI,EDV,AC,SW,CW,SWI and CWI,while positively correlated with PEP/LVET and AMP O.Conclusions： There exists certain relevance between the index of cardiac hemodynamics and the level of plasma NT-proBNP in Patients with ACS.