摘要
研究白花蛇舌草注射液对荷瘤小鼠免疫功能的影响。应用比色法,分别测定白花蛇舌草注射液在高(15 mg生药/kg)、中(7.5 mg生药/kg)、低(3.75 mg生药/kg)3种剂量作用下,荷瘤小鼠脾脏NK细胞毒指数、脾细胞的增殖、腹腔巨噬细胞吞噬百分率及指数、血清凝集素活性和脾细胞IL-2活性的变化。与荷瘤对照组比较,白花蛇舌草注射液各剂量组可显著提高NK细胞活性(P<0.01,P<0.05);增强脾细胞增殖(P<0.01,P<0.05);显著提高腹腔巨噬细胞的吞噬功能(P<0.001,P<0.01,P<0.05);显著增加血清中抗羊红细胞凝集素值(P<0.001、P<0.01);高、中剂量组可明显提高脾脏IL-2活性(P<0.01,P<0.05)。白花蛇舌草注射液具有显著提高荷瘤小鼠免疫功能的作用。
To study the effects of Hedyotis diffusa injection on immune function of tumor-bearing mice. The following items were determined by using colorimetry： Cytotoxic index of the NK cells, proliferation of the spleen ceils, phagocytic percentage and the index of the abdomen macrophages, agglutinating activity from serum to the sheep erythrocytes and IL-2 activity of the spleen ceils in the tumor-bearing mice treated with high-,moderate- or low-dosage of Hedyotis diffusa injection （15,7.5,3.25 mg per kilogram ）. Compared to the tumor-bearing groups, the cytotoxic index of the NK cells, proliferation of the spleen cells, phagocytic percentage and the index of the abdomen macrophages, agglutinating activity increased significantly（ P 〈 0.001, P 〈 0.01, P 〈 0.05 ）. The IL-2 activity increased significantly at high and moderate-dosage （P 〈 0.01, P 〈 0.05 ）. The Hedyotis diffusa injection plays an important role in enhancing the immune function of tumor-bearing mice.
出处
《特产研究》
2010年第3期5-7,12,共4页
Special Wild Economic Animal and Plant Research
