β内酰胺类与大环内酯类抗菌药物能否联用

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摘要《中国乡村医药》编辑：你们好!2010年第4期49页《2005-2009年我院抗菌药物配伍不合理处方分析》中提到＂β内酰胺类药物与大环内酯类二者不宜联用,可产生拮抗作用＂。而同期第80页执业助理医师继续教育讲座栏目中《老年人肺炎》一文建议：β内酰胺类药物与大环内酯类二者联合用于治疗老年人肺炎。

作者郝香山李一鸣

机构地区不详中日友好医院呼吸内科

出处《中国乡村医药》 2010年第10期84-84,共1页

关键词 β内酰胺类药物大环内酯类抗菌药物老年人肺炎执业助理医师 2009年处方分析药物配伍

参考文献7

1Lepper HM,Dowlling HF. Treatment of pneumococci meningtitis with penicillin compared with penicillin plus aureomycin[J]. AMA Arch Intern Med, 1951,88:489-494.
2Waterer GW, Somes GW, Wunderink RG. Monotherapy may be suboptimal for severe bacteremic pneumococcal pneumoniae[J]. Arch Intern Med, 2001, 161:1837-1842.
3Martinez JA, Horcajada JP, Almela M, et ah Addition of a macrolide to a beta-lactams regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia[J]. Clin Infect Dis,2003,36:389-395.
4Garcia VE, Mensa J, Martinez JA, et al. Lower mortality among patients with oommunity-acquired pneumonia treated with a macrolide plus a beta-lactam agent versus a beta-lactam agent alone[J].Eur J Clin Microbiol Infect Dis,2005,24:190-195.
5Youning Liu, Minjun Chen, Tiemei Zhao,et al. Causative agent distribution and antibiotic therapy assessment among adult patients with community acquired pneumonia in Chinese urban population[J]. BMC Infectious Diseases, 2009,9:31-39.
6Karlstrom A, Boyd KL, English BK, et al. Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza[J], J Infect Dis,2009, 199: 311-319.
7Lagrou K, Peetermans WE, Jorissen M, et al. Subinhibitory concentrations of erythromycin reduce pneumococcal adherence to respiratory epithelial cells in vitro[J]. J Antimicrob Chemother, 2000, 46:717-723.

中国乡村医药

2010年第10期

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