冠心病患者血清白介素-18和超敏c反应蛋白检测的临床意义

Changes of Plasma Interleukin- 18 and High Sensitivity C- reactive Protein and the Clinical Significance in Patients with Coronary Heart Disease

目的探讨白介素-18（IL-18）、超敏c反应蛋白（hs—CRP）水平与冠心病（CHD）及冠状动脉病变程度的关系。方法采用酶联免疫吸附法测定27例稳定心绞痛（SAP），33例不稳定心绞痛（UAP），28例心肌梗死（AMI）及95例正常健康者血清白介素-18、超敏c反应蛋白的水平。结果CHD患者血清IL-18、hs—CRP水平明显高于健康对照组（P〈0．05）；AMI患者血清IL-18、CRP水平显著高于UAP及SAP患者，UAP患者血清IL-18、CRP水平高于SAP患者（P〈0．05）。随着冠脉病变程度的加重，两者水平变化差别无统计学意义（P〉0．05）。结论白介素18、超敏C反应蛋白水平可以作为冠心病危险性的预测因子。

Objective To explore the relations between interleukin- 18 （IL- 18 ）and high sensitivity C -reactive protein（ hs - CRP） in the patients with coronary heart disease. Methods The serum levels of IL - 18 and hs - CRP were measured by ELISA in 27 cases of SAP group,33 cases of UAP group,28 cases of AMI group and 95 cases of normal group. Results The serum level of IL - 8 and hs - CRP in the cases of AMI group, UAP group, SAP group were obviously higher than those of normal controls. And the level of AMI group was the highest（ P 〈 0.05 ）. The levels of IL - 18 and hs - CRP were of no diference existed in different vessels disease groups（ P 〉 0.05 ）. Conclusion IL - 18 and hs - CRP may be important risk factors for the development of CHD.