体重指数和腰身比值与多囊卵巢综合征患者糖耐量异常的相关性

Correlation analysis of abnormal glucose tolerance and body mass index and waist-height ratio in women with polycystic ovary syndrome

目的:探讨多囊卵巢综合征(PCOS)糖耐量异常的发生率及体重指数和腰身比值预测PCOS患者糖耐量异常的可靠性。方法:选择2004年1月～2007年12月期间青岛大学医学院附属烟台毓璜顶医院接诊的192例14～39岁的PCOS患者(其中14～19岁的青春期PCOS患者57例、20～39岁的成年女性病例135例),测定体重指数和腰身比值;测定空腹血糖水平并行口服糖耐量试验。结果:21.4%的PCOS患者糖耐量异常,其中12.3%的青春期患者和25.2%的成年患者糖耐量异常。分别比较青春期和成年PCOS患者糖耐量异常与糖耐量正常者之间体重指数和腰身比值的差异,两组体重指数之间不存在显著性差异(P>0.05),而腰身比值存在显著性差异(P<0.05)。结论:单纯体重指数不能用于预测PCOS患者糖耐量异常的发生,而腰身比值可作为预测PCOS患者糖耐量异常发生的简易指标。

Objective：To investigate the incidence of abnormal glucose tolerance （AGT） in women with polycystic ovary syndrome （PCOS）,and explore the reliability of body mass index and waist-height ratio（WHtR） as a predictive index for the occurrence of abnormal glucose tolerance.Methods：192 women （57 adolescents and 135 adults） diagnosed with PCOS underwent estimation of fasting blood glucose and 2-h plasma glucose after ingestion of 75g of glucose on an empty stomach in Yuhuangding Hospital from January,2004 to December,2007.In each case,body mass index （BMI） and waist-height ratio（WHtR） were calculated respectively.Results：Abnormal glucose tolerance was found in 21.4% of cases（41/192）,and found in 12.3% of adolescent cases and 25.2% of adults.Women with abnormal glucose tolerance had higher BMI than those with normal glucose tolerance in adolescent cases and adult cases respectively（not statistically significant）.However,there was significant difference between the two subgroups for the waist-height ratio.Difference in BMI between adults and adolescents with normal glucose tolerance was statistically significant,but not in cases with AGT.But difference in waist-height ratio between adults and adolescents with abnormal glucose tolerance was statistically significant,but not in cases with normal glucose tolerance.Conclusion：BMI alone is not a significant contributory factor causing deterioration of glucose tolerance as a woman with PCOS matures.Other clinical parameters of obesity such as upper body obesity need to be studied.Waist-height ratio is one more significant and predictive index for the occurrence of abnormal glucose tolerance.