基质金属蛋白酶-2及其组织抑制物-2在动脉粥样硬化兔主动脉中的表达变化被引量：2

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摘要目的研究基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)及基质金属蛋白酶组织抑制物-2(tissue inhibitor of metalloproteinases-2,TIMP-2)在动脉粥样硬化兔主动脉组织中的表达及与血管病理改变的关系。方法 16只雄性新西兰兔随机分为对照组(喂食普通兔料)、高脂模型组(喂食高脂饲料),饲养12周后处死动物,取主动脉进行病理学检查,并采用RT-PCR方法来检测主动脉病灶中MMP-2和TIMP-2 mRNA的表达。结果 MMP-2 mRNA在正常对照主动脉组织中低表达而在动脉粥样硬化病变时高表达;TIMP-2 mR-NA在正常对照主动脉组织中高表达而在动脉粥样硬化病变时低表达。结论 MMP-2及TIMP-2的协同表达在动脉粥样硬化及动脉血管重塑过程中起作用,动脉粥样硬化的发生与两者的比例失调有关。

作者姜昕郭毅左彦方李方明刘华东庞新华

机构地区暨南大学第二临床医学院广东省深圳市人民医院心内科广东省深圳市人民医院神经内科

出处《广东医学》 CAS CSCD 北大核心 2010年第17期2244-2245,共2页 Guangdong Medical Journal

关键词基质金属蛋白酶-2 金属蛋白酶组织抑制物-2 动脉粥样硬化

分类号 R737.14 [医药卫生—肿瘤]

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