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鼻咽癌组织中HIF-2α和CA Ⅸ的表达及其意义 被引量：2

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摘要 目的探讨乏氧诱导因子2α(HIF-2α)和碳酸酐酶Ⅸ(CAⅨ)蛋白在鼻咽癌组织中的表达及其临床意义。方法应用免疫组化法检测46例初诊鼻咽癌组织和20例鼻咽慢性炎性组织中HIF-2α和CAⅨ蛋白的表达,并对17例鼻咽癌患者放疗前、放疗期间(36 Gy)鼻咽癌活检组织中HIF-2α和CAⅨ的蛋白表达进行动态检测。结果鼻咽癌组织中HIF-2α及CAⅨ蛋白的阳性率分别高于鼻咽慢性炎性组织,且差异有显著性(P<0.01);HIF-2α蛋白表达与患者性别、年龄、颈部淋巴结转移状态及临床分期无明显相关(P>0.05),与T分期的早晚相关(P<0.05)。CAⅨ蛋白的表达与患者的性别、年龄、T分期、颈部淋巴结转移状态及临床分期无明显相关(P>0.05)。鼻咽癌组织中HIF-2α和CAⅨ蛋白的阳性表达有相关性(r=0.467,P<0.05)。17例动态观察的鼻咽癌患者,其放疗前HIF-2α和CAⅨ蛋白阳性表达率高于放疗期间,且差异有显著性(P<0.05)。结论 HIF-2α和CAⅨ蛋白过表达可能涉及鼻咽癌的发生和发展过程;HIF-2α和CAⅨ蛋白在鼻咽癌组织中的表达可能具有协同作用。
作者 杨东 李先明 高艳 周亚燕 丁晖 刘湘园 徐钢 吴事海
机构地区 暨南大学第二临床医学院 广东省深圳市人民医院肿瘤放疗科
出处 《广东医学》 CAS CSCD 北大核心 2010年第17期2265-2268,共4页 Guangdong Medical Journal
基金 广东省深圳市科技计划项目(编号:200702102)
关键词 鼻咽肿瘤 乏氧诱导因子2α 碳酸酐酶Ⅸ 免疫组织化学
分类号 R739.63 [医药卫生—肿瘤]
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共引文献17

同被引文献34

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二级引证文献4

广东医学
2010年 第17期

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