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同型半胱氨酸代谢酶基因与心脏发育关系的研究进展 被引量：1

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摘要 脊椎动物体内同型半胱氨酸（homocysteine,Hcy）的产生有两条必经途径：复甲基化形成蛋氨酸,转硫基与丝氨酸缩合生成胱硫醚。血清Hcy浓度主要由这两条代谢途径中的三个关键酶[亚甲基四氢叶酸还原酶（MTHFR）、胱硫醚β合成酶（CBS）、蛋氨酸合成酶（MS）]参与决定。在中国北方人口中MTHFR、CBS、MS突变体等位基因出现的频率依次是51.18%、7.58%、2.36%,
作者 王晓琼 仇小强
机构地区 桂林医学院附属医院心内科
出处 《广东医学》 CAS CSCD 北大核心 2010年第17期2319-2321,共3页 Guangdong Medical Journal
基金 广西壮族自治区自然科学基金资助项目(编号:2010GXNSFD013054)
关键词 体内同型半胱氨酸 代谢酶基因 心脏发育 胱硫醚Β合成酶 亚甲基四氢叶酸还原酶 蛋氨酸合成酶 MTHFR 脊椎动物
分类号 R587.1 [医药卫生—内分泌]
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二级参考文献45

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共引文献137

同被引文献15

  • 1张成森,潘旭东,刘翠薇.中国青岛汉族人群亚甲基四氢叶酸还原酶基因多态性分布研究[J].齐鲁医学杂志,2005,20(4):310-312. 被引量：10
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  • 8Bhargava S,Ali A,Parakh R, et al. Higher incidence ofC677T polymorphism of the MTHFR gene in North Indi-an patients with vascular disease[J], Vascular, 2012, 20(2).88-95.
  • 9Jakovljevic K.Malisic E, Cavic M,et al. Association be-tween methylenetetrahydrofolate reductase polymorphismC677T and risk of chronic myeloid leukemia in Serbianpopulation[J]. Leuk Lymphoma,2012,53(7) : 1327-1330.
  • 10Han Y,Pan Y,Du Y,et aL Methylenetetrahydrofolate re-ductase C677T and A1298C polymorphisms and nonsyn-dromic orofacial clefts susceptibility in a southern Chinesepopulation[J].DNA Cell Biol,2011,30(12) : 1063-1068.

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广东医学
2010年 第17期

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