含左氧氟沙星三联方案根除幽门螺杆菌的疗效观察

Efficacy of levofloxacin-based triple therapy in first-line treatment for helicobacter pylori eradication.

目的观察含左氧氟沙星三联方案作为一线治疗根除幽门螺杆菌(HP)在本地区(成都市)的疗效。方法纳入120例诊断为消化性溃疡、慢性糜烂性胃炎、慢性萎缩性胃炎伴HP感染的患者。随机分为A、B、C三组。A组采用埃索美拉唑(E)20 mg+克拉霉素(C)500mg+甲硝唑(M)400mg,均2次/d,B组E 20mg+C 500mg+阿莫西林(A)1.0g均2次/d,C组E20mg 2次/d+左氧氟沙星(L)500mg 1次/d+A 1.0g 2次/d治疗,疗程7d。观察疗效。结果 109例完成实验。HP根除率:A组63.9%,B组88.9%,C组89.2%。B、C组HP根除率差异无统计学意义(P>0.05),但均明显高于A组(P<0.05)。结论 ECA及ELA方案HP根除率明显高于ECM方案,可能更适合于本地区根除HP的一线治疗。

Objective To observe the efficacy of levofloxacin-based triple therapy in first-line treatment for helicobacter pylori eradication.Methods One hundred and twenty patients diagnosed as peptic ulcer,chronic erosive gastritis and chronic atrophic gastritis with HP Infection were included and randomly divided into three groups.A group was administered with esomeprazole（E）20mg bid,clarithromycin（C）500mg bid and metronidazole（M）400mg bid,B group received E and C combined with amoxicillin（A） 1.0g bid,C group received E and A combined with levofloxacin（L）500mg qd for 7 days.The efficacy was observed.Results One hundred and nine patients completed the study.The HP eradication rates were：A group 63.9%,B group 88.9%,C group 89.2%.The eradication rate of A group was lower than B and C group（P0.05）,but no difference was found between B and C group（P0.05）.Conclusion The HP eradication rates of ECA and ELA triple therapy were significantly higher than the ECM regimen.It may be better to choose the former two therapies as the first-line therapy in Chengdu.