结节性红斑283例临床分析

Clincal analysis of 283 patients with erythema nodosum.

目的探讨结节性红斑的病因、临床特点及治疗方法。方法对我院皮肤科门诊1999~2009年283例结节性红斑患者进行分析。结果该病多见于中青年患者,男∶女比例为1∶6.8;病因：感染（结核杆菌感染33.22%,链球菌感染22.26%）;结缔组织疾病19例（6.71%）,其中白塞病（BD）5例（1.77%）,干燥综合征（ss）2例（0.07%）,系统性红斑狼疮（SLE）5例（1.77%）,类风湿关节炎（RA）4例（1.41%）;淋巴瘤2例（0.89%）,病因不明66例（23.32%）。结论结节性红斑为多因素疾病,与感染性疾病最为密切,多见于结核杆菌及链球菌感染。治疗应积极驱除病因和对症治疗。

Objective To analyze the etiology,clinical features and treatment of the erythema nodosum（EN）.Methods A total of 283 patients with a diagnosis of EN between 1999 and 2009 in our hospital were included in the study retrospectively.Results It affected mainly middle-aged people,and the propotion of men and women was 1∶6.8.The foremost etiology was tuberculosis infection（33.22%） followed in decreasing order by streptococcal infection（22.26%）;Connective tissue disease（6.71%）：Behcet disease（1.77%）,Sjogren syndrome（0.07%）,Systemic Lupus Erythematosus（1.77%） rheumatoid arthritis（1.41%）;lymphoma（0.89%）;unknow causes（23.32%）.The outcomes were usually favourable.Conclusion EN is a multiple-factor disease,closely involved with infection,and the common infections are caused by tubercle bacillus and streptococcal bacterium.Etiology and symptomatic treatment are very importent.