小剂量促红细胞生成素及铁剂治疗慢性心力衰竭合并贫血

Small dose of erythropoietin and clialybeate in the treatment of congestive heart failure patients with anemia.

目的探讨小剂量促红细胞生成素及铁剂对充血性心力衰竭(congestive heart failer,CHF)合并贫血的疗效及安全性。方法将98例患者随机分为两组,对照组用血管紧张素转换酶抑制剂(ACEI)或血管紧张素受体拮抗剂(ARB)、洋地黄、利尿剂、美托洛尔等内科常规治疗,治疗组在对照组基础上加用小剂量促红细胞生成素及铁剂,定期复查血常规,血红蛋白达110g/L后停用促红细胞生成素及铁剂,继续其他治疗,其他患者继续原治疗方案,疗程为4个月。结果治疗组比对照组总有效率提高(P<0.01),左室射血分数(left ventricular ejection fraction,LVEF)升高(P<0.01)。结论小剂量促红细胞生成素(EPO)及铁剂是治疗CHF合并贫血的安全、有效的药物。

Objective To invetigate the curative effect in the treatment of small dose of erythropoietin and chalybeate in patients with congestive heart failure（CHF） and anemia.Methods 98 cases were randomly divided into two grourps： In the control group,paitents were treated with angiotensin converting enzyme inhibitor（ACEI） or angiotensin-receptor blockers（ARB）,diuretics,digitalis,betaloc and conventional therapy for 4 months.In the base of control group therapy,paitents in the rapeutic group were treated with small dose of erythropoietin and chalybeate.The erythropoietin and chalybeate will be continued until the haemoglobin comes up to 110g/L,the other treatment will be continued for 4 months.Results The whole effective rates of the rapeutic group was higher than that of the control group（P0.01）.The left ventricular ejection fraction of the rapeutic group was higher than that of the control group（P0.01）.Conclusion Small dose of erythropoietin and chalybeate was effective and safe in treating CHF.