摘要
为了寻求新的高效的三唑类杀菌剂,在文献研究的基础上,根据生物活性叠加原理,把醚键引入到化合物分子中,设计了一系列含有醚键和α,β-不饱和酮结构的新型三唑类化合物。以对羟基苯乙酮、取代苯甲醛、多聚甲醛和1H-1,2,4-三氮唑为原料,经过氯甲基化、羟醛缩合、醚化等步骤,合成了目标化合物,并通过IR、1HNMR和MS等手段确证了所合成化合物结构的正确性。采用离体平皿法,对目标化合物进行了生物活性测试,结果表明合成的部分目标化合物具有一定的杀菌活性。
In order to seek novel highly active triazole compounds, based on literature studing, according to principle of activities superposition, a series of novel triazole compounds containing ether link and α,β-unsaturate ketone structure were synthesized through introducing ether link into compound molecules. Target compounds were synthesized through chloromethylation, condensation and etherification reaction using p-hydroxy phenyt ethyl ketone, substitutive phenyl aldehyde, paraform and 1H-1,2,4-triazole. Their structures were confirmed by IR, ^1H NMR and MS. Using vitro plate method, biological activities of all synthesized target compounds were tested. Biological activities test shows that the part of synthesized compounds exhibit some fungicidal activities.
出处
《农药》
CAS
北大核心
2010年第9期645-647,649,共4页
Agrochemicals
关键词
三氮唑
醚键
合成
生物活性
triazole
ether link
synthesis
biological activities