转铁蛋白的研究进展

Study Progress of Transferrin

转铁蛋白(Transferrin,TRF,TF,又称为铁传递蛋白、血清运铁蛋白、运铁蛋白、嗜铁蛋白、铁糖蛋白)是一种重要的β-球蛋白,是脊椎动物体内铁的运输者。1945年,Holmberg和Laurell首次在人血清中发现了这种非血红素结合铁的转铁蛋白,此后人们又在哺乳动物以及鱼类、两栖类及爬行类的血清中分别发现了转铁蛋白的存在。由于在抗菌、杀菌以及在肿瘤和癌症防治等方面的突出作用,转铁蛋白在医药界已越来越受到人们的重视并开展了转铁蛋白作为药物载体的大量研究。

Transferrin（TRF,TF） is a kind of important beta globulin,vertebrates iron shippers.In 1945,Holmberg and Laurell first in serum found this combination nonheme iron transferrin,then people in mammals and fish,amphibians and reptiles were found in serum transferrin existence.Due to the antibacterial,sterilization and tumor and cancer preven-tion,etc,transferrin in pharmaceutical industry has become more and more attention,people developed transferrin as drug carrier of research.