缬沙坦和左旋氨氯地平治疗原发性高血压的疗效及对血尿酸的影响

目的:比较缬沙坦和左旋氨氯地平的降压效果及两者对血尿酸的影响。方法:将76例原发性高血压伴高尿酸血症患者随机分成缬沙坦和左旋氨氯地平组,观察2组治疗前后血压和血尿酸的变化。结果:2组治疗后血压均较治疗前下降(P<0.05),缬沙坦组治疗后较治疗前血尿酸水平明显降低(P<0.05);左旋氨氯地平组治疗后较治疗前血尿酸水平差异无统计学意义(P>0.05)。结论:缬沙坦和左旋氨氯地平降压效果相似,缬沙坦除降压外,还可降低血尿酸水平,对高血压伴高尿酸血症患者应首选缬沙坦。

Objective：To compare the valsartan and Levamlodipine hypotensive effect and the impact of both on blood uric acid.Methods：76 cases of primary hypertension with hyperuricemia were randomly divided into valsartan and Levamlodipine groups before and after treatment were observed for 2 blood pressure and blood uric acid changes.Results：Group 2 after treatment than before treatment,blood pressure decreased （P0.05）,valsartan group after treatment than before treatment significantly decreased serum uric acid levels （P0.05）;Levamlodipine group after treatment than before treatment,serum uric acid no significant difference between levels （P0.05）.Conclusions：Valsartan and Levamlodipine hypotensive effect similar,valsartan addition to blood pressure,it can also lower blood uric acid levels in hypertensive patients,with hyperuricemia should be preferred valsartan.